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TITLE       The use of Blumea balsamifera (Sambong) in the dissolution of urinary stone: An in-vitro study
LOCATION(S)      PCHRD 
PUBLICATION TITLE      Philippine Journal of Urology
VOLUME/ISSUE      16(1)
PAGINATION/COLLATION      6-10
MAIN AUTHOR      Vinco, Julian Salvador A
ADDED ENTRY      Sunga, Paul Anthony L
ABSTRACT      

OBJECTIVE: To determine if Blumea balsamifera (Sambong) decoction can dissolve urolithiasis in vitro.

MATERIALS AND METHODS: Twelve urinary calculi were taken from patients who underwent stone surgery in UERMMMC. These stones were fragmented and divided into two equal groups. The control group was irrigated using the patient's urine for 72 hours. The study group was irrigated with sambong decoction and patient's urine for 72 hours. The reduction in initial weight and size, percentage weight loss and dissolution rate were determined and analyzed using paired t-test.

RESULTS: There was no change in dry weight and size in the control group. In the study group, eight stones decreased in size and weight in 72 hours of irrigation. Three had no change in initial weight and size. The mean weight loss was 0.158 gms +/- 0.215, the mean percentage weight loss was 15 percent in 72 hours of irrigation. The mean dissolution rate was 0.002 gm/hr. The percent stone weight loss and dissolution rate were statistically significant at p value of < 0.05 using the paired t-test. Uric acid stones had a mean percentage weight loss of 32.25 percent in 72 hours and a dissolution rate of 0.00525 gm/hr compared to calcium stones which had a percentage weight loss of 6.8 percent in 72 hours and a mean dissolution rate of 0.0006 gm/hr while struvite (magnesium-ammonium-phosphate) stones had a mean percentage weight loss of 5 percent in 72 hours and a mean stone dissolution rate of 0.0005 gm/hr.

CONCLUSION: Sambong used in-vitro was able to dissolve urinary stones. However, it was able to dissolve uric acid stones faster. This is most probably due to the pH of the solution which was ideal in dissolving uric acid stones. No significant dissolution was noted in the struvite and calcium stones which were studied. (Author)

SUBJECTS       Urinary calculi
   Urologic diseases
   Plants, medicinal
   Blumea balsamifera
   Sambong
   Urolithiasis
   Dissolution
   Uric acid stones
   Urinary stones
   In-vitro study
   In-vitro
   Urinary calculi
   Urologic diseases
   Plants, medicinal
   
 
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